Blog

The 5 commercial mistakes
that cost deeptech startups dearly.

After working with deeptech and biotech founders — and having walked this path myself — I've seen the same mistakes repeated. Not from lack of intelligence or effort. But because the instincts that make great scientists often make poor salespeople.

These five mistakes are not major blunders. They are subtle, structural, and mutually reinforcing. That's precisely what makes them dangerous.

Mistake #1 — Waiting for the technology to be perfect

This is by far the most frequent and most costly mistake. The logic is understandable: you don't want to present something incomplete, risk being judged poorly, or promise what you can't yet deliver.

The problem is that "ready" is a moving horizon. There will always be another validation to run, a parameter to optimise, an uncertainty to resolve. And in the meantime, you're missing the conversations that would tell you whether you're heading in the right direction.

What to do instead: engage exploratory conversations early, with identified counterparts, being transparent about your development stage. An industrial player who says "come back when it's ready" gives you useful information. One who engages in a conversation gives you something invaluable.

Mistake #2 — Pitching the technology instead of the problem solved

Deeptech founders often have a legitimate fascination with their technology. They talk about it with passion, precision, and depth. The problem is that their industrial counterpart doesn't wake up thinking about your technology. They wake up thinking about their problems.

A technical director at a pharmaceutical group isn't looking for "a new continuous flow synthesis process." They're looking to reduce their development time from 18 to 12 months on their next molecule. Technology is a means. The problem is the door.

What to do instead: before each approach, answer this question: what specific problem of this person does my technology solve — in their terms, not mine?

Mistake #3 — Targeting "the industry" instead of a specific person

"We target the pharmaceutical industry", "we address major energy groups." These formulations are non-targets. An industry doesn't make decisions. A person, in a function, with specific objectives and a budget, does.

An industrial partnership isn't signed with "the sector." It's signed with an R&D director, an innovation manager, a project leader who has a problem to solve and a budget to do it. Identifying that person — their role, their KPIs, their constraints, their decision-making authority — is the prerequisite for any serious approach.

What to do instead: for each potential target, identify the contact by name, their exact function, and the precise reason why your technology should be on their agenda.

Mistake #4 — Confusing "very interesting" with commitment

This is perhaps the most painful mistake, because it occurs after weeks or months of effort. You've had good meetings, positive feedback, requests for additional documentation. Your contact is enthusiastic. And then… nothing.

The problem is that an industrial player saying "very interesting" is often really saying: "I don't see a reason to dismiss you, but I also don't see a reason to commit right now." The interest is real. The urgency is not.

What to do instead: at each exchange, seek to identify the next concrete step and who owns it. A budget proposal, access to equipment, a meeting with another decision-maker. Without a defined next step, an enthusiastic meeting is a lost meeting.

Mistake #5 — Using the same pitch as with investors

This point deserves an article of its own — and it has one. But to summarise: investors and industrial players have radically different decision frameworks. Investors seek upside, growth, an ambitious market vision. Industrial players seek to reduce their risks, improve their processes, integrate a technology into their existing value chain.

A pitch that excites an investor — "€50 billion addressable market, 10x growth, sector disruption" — can literally frighten a technical director who has to justify to their senior management why they're committing money to an 8-person startup.

What to do instead: build two distinct pitches. Not two versions of the same document — two different narrative logics, designed for two types of counterparts with opposing decision criteria.


These five mistakes share a common thread: they all stem from a technology- or startup-centred view, rather than a focus on the industrial counterpart and their real constraints. The shift in perspective — from "here's what I do" to "here's the problem I solve for you" — is the central pivot of all successful deeptech commercialisation.

It doesn't come naturally. It's learned.

Recognise some of these mistakes in your approach?

An initial conversation to identify the adjustments that will make the difference in your commercial strategy.

Get in touch